Direct Assembly of Prenylated Heteroarenes through a Cascade Minisci Reaction/Dehydration Sequence
نویسندگان
چکیده
The prenyl group is an important component in bioactive compounds. Herein, we report the assembly of prenylated heteroarenes through a cascade Minisci reaction and acid-promoted dehydration sequence. The use of potassium (3-hydroxy-3-methylbut-1-yl)trifluoroborate as a new coupling reagent allows the direct introduction of prenyl and 3-hydroxy-3-methylbutyl groups to a wide variety of electron-deficient heteroarenes. Synthetic application is also demonstrated.
منابع مشابه
Direct α-arylation of ethers through the combination of photoredox-mediated C-H functionalization and the Minisci reaction.
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Correction for 'Photoredox-mediated Minisci C-H alkylation of N-heteroarenes using boronic acids and hypervalent iodine' by Guo-Xing Li et al., Chem. Sci., 2016, DOI: ; 10.1039/c6sc02653b.
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عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2016